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New study gives the most detailed look yet at the neuroscience of placebo effects

 E-Mail IMAGE: fMRI activity during pain is reduced in the areas shown in blue. Many of these are involved in constructing the experience of pain, including the feeling of suffering, and motivating. view more  Credit: Image provided by M.Zunhammer et al. A large proportion of the benefit that a person gets from taking a real drug or receiving a treatment to alleviate pain is due to an individual s mindset, not to the drug itself. Understanding the neural mechanisms driving this placebo effect has been a longstanding question. A meta-analysis published in Nature Communications finds that placebo treatments to reduce pain, known as placebo analgesia, reduce pain-related activity in multiple areas of the brain.

Will my face stay like this forever? : How it feels to have Bell s palsy

Emma was on holiday with her family two days before she developed Bell s palsy Have you heard of Bell’s palsy? I certainly hadn’t, until it paralysed one side of my face. My eldest son and I were in the garden in our pyjamas, picking blackberries. It was a lovely summer’s morning and we’d just come home from a family holiday in France. My husband, Will, was taking photos of us but I couldn’t smile properly. It was the strangest feeling. I ignored it, as busy mums of small children often do with things concerning themselves, but the right side of my face felt heavier and when I looked in the mirror, my eyebrow had dropped and my mouth was lopsided.

Potential drug for Alzheimer s disease prevention found safe and effective in animals

 E-Mail IMAGE: Compared with a control (left), treatment with the novel GSM (right) reduces the number of amyloid plaques (green) and proinflammatory cells called microglia (magenta) in the brains of mice carrying. view more  Credit: ©2021 Rynearson et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20202560 Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer s disease by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques in the brain. The study, which will be published March 2 in the JEM), demonstrates that the drug is safe and effective in rodents and monkeys, paving the way for future clinical trials in humans.

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